currentsinbiology:

New type of cell movement discovered
In a new study from the University of Pennsylvania and National Institute of Dental and Craniofacial Research, scientists used an innovative technique to study how cells move in a three-dimensional matrix, similar to the structure of certain tissues, such as the skin. They discovered an entirely new type of cell movement whereby the nucleus helps propel cells through the matrix like a piston in an engine, generating pressure that thrusts the cell’s plasma membrane forward.

"Our work elucidated a highly intriguing question: how cells move when they are in the complex and physiologically relevant environment of a 3-D extracellular matrix," said Hyun (Michel) Koo, a professor in the Department of Orthodontics at Penn’s School of Dental Medicine. "We discovered that the nucleus can act as a piston that physically compartmentalizes the cell cytoplasm and increases the hydrostatic pressure driving the cell motility within a 3-D matrix."

R. J. Petrie, H. Koo, K. M. Yamada. Generation of compartmentalized pressure by a nuclear piston governs cell motility in a 3D matrix. Science, 2014; 345 (6200): 1062 DOI: 10.1126/science.1256965
Penn and NIH researchers measured the internal pressure of individual fibroblast cells (in orange) moving through a three-dimensional matrix (in blue). They found that, in this environment, the cells’ nuclei operate like an engine’s piston to push the cell forward.  Credit: University of Pennsylvania/NIDCR

currentsinbiology:

New type of cell movement discovered

In a new study from the University of Pennsylvania and National Institute of Dental and Craniofacial Research, scientists used an innovative technique to study how cells move in a three-dimensional matrix, similar to the structure of certain tissues, such as the skin. They discovered an entirely new type of cell movement whereby the nucleus helps propel cells through the matrix like a piston in an engine, generating pressure that thrusts the cell’s plasma membrane forward.

"Our work elucidated a highly intriguing question: how cells move when they are in the complex and physiologically relevant environment of a 3-D extracellular matrix," said Hyun (Michel) Koo, a professor in the Department of Orthodontics at Penn’s School of Dental Medicine. "We discovered that the nucleus can act as a piston that physically compartmentalizes the cell cytoplasm and increases the hydrostatic pressure driving the cell motility within a 3-D matrix."

R. J. Petrie, H. Koo, K. M. Yamada. Generation of compartmentalized pressure by a nuclear piston governs cell motility in a 3D matrix. Science, 2014; 345 (6200): 1062 DOI: 10.1126/science.1256965

Penn and NIH researchers measured the internal pressure of individual fibroblast cells (in orange) moving through a three-dimensional matrix (in blue). They found that, in this environment, the cells’ nuclei operate like an engine’s piston to push the cell forward.  Credit: University of Pennsylvania/NIDCR

browneyedanachronism:

spokenunspoken:

shaky:

I’m stuck between wanting:

1. A long lasting relationship with my soulmate who supports me and protects me and is my partner and we are completely bad ass together and in love

2. Wanting to have casual sex and rip out the heart of everyone person I meet

3. Being independent and having a loyal dog while I’m married to my career

It scares me how accurate this is.

(via abombyadig)

There are a few things in life so beautiful they hurt: swimming in the ocean while it rains, reading alone in empty libraries, the sea of stars that appear when you’re miles away from the neon lights of the city, bars after 2am, walking in the wilderness, all the phases of the moon, the things we do not know about the universe, and you. Beau Taplin || and you (via elfyclo)

(via abombyadig)

so-personal:

everything personal

so-personal:

everything personal

(via abombyadig)

so-personal:

everything personal

so-personal:

everything personal

(via abombyadig)

fauxyshazam:

"if you’re straight and white tumblr will lynch you~"

fun fact!! there are actual places in the real irl world today (2014!) where if you are anything other than straight and white you will actually get lynched! literally! they will literally kill you!! isn’t that wild??

(via joshpeck)

thebagofholding:

“man i am so tired” stays up for 3 more hours doing absolutely nothing

(via joshpeck)